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Psychosocial therapy and pharmacologic medication may be necessary to help the patient deal with the stressful events associated with BMT pre-transplant, during hospitalization, and after discharge. Psychosocial therapy alone or in combination with a pharmacologic medication has been utilized to successfully to decrease depressive symptoms in cancer patients (Holland & Alici, 2010). Randomized controlled trials (RCT) and more adequately powered research studies are needed to explicitly test the efficiency of pharmacotherapy and psychotherapy in managing distress/depression among BMT patient population (Jacobsen & Jim, 2008; Pirl, 2004; Williams & Dale, 2006) A detailed assessment of BMT recipient’s emotional, social, and psychological well-being before BMT is necessary to provide optimal, holistic care. Distress and depression should be recognized, monitored, documented and treated promptly during the BMT treatment. BMT patients need to be screened at their pre-transplant appointment, at appropriate intervals, and as clinically indicated during the BMT process. Distress and depression should be recognized, monitored, documented and treated promptly during the BMT process to ensure positive patient outcomes. References: Andykowski, M., Bishop, M., Hahn, E., Cella, D., Beaumont, J., Brady, M., Horowitz, M., Sobocinski, K., Rizzo, D., & Wingard, J. (2005). Long term health related quality of life, growth, and spiritual well-being after hematopoietic stem cell transplantation. Journal of Clinical Oncology, 23(3), 599-608. Carlson, L. & Bultz, B. (2003). Cancer distress screening: needs, models, and methods. Journal of Psychosomatic Research, 55, 403-409. Colon, E., Callies, A., Popkin, M., & McGlave, P. (1991). Psychosomatics, 32(4), 420-425. Fife, B. L., Huster, G. A., Cornetta, K. G., Kennedy, V. N., Akard, L. P., & Broun, E. R. (2000). Longitudinal study of adaptation to the stress of bone marrow transplantation. Journal of Clinical Oncology, 18(7), 1539-1549. Frick, E., Motzke, C., Fischer, N., Busch, R., & Bumeder, I. (2005). Is perceived social support a predictor of survival for patients undergoing autologous peripheral blood stem cell transplantation? Psycho-Oncology, 14, 759-770. Gabriel, B., Bromberg, E., Vandenbovenkamp, J., Walka, P., Kornblith, B., & Luzzatto, P. (2001). Art therapy with adult bone marrow transplant patients in isolation: a pilot study. Psycho-Oncology, 10, 114-123. Goetzmann, L., Klaghofer, R., Wagner-Huber, R., Halter, J., Boehler, A., Muellhaupt, B., Schanz, U., & Buddeberg, C. (2007). Psychosocial vulnerability predict psychosocial outcome after an organ transplant: results of a prospective study with lung, liver, and bone marrow patients. Journal of Psychosomatic Research, 62, 93- 100. Holland, J. & Alici, Y. (2010). Management of distress in cancer patients. Journal of Supportive Oncology, 8(1), 4-12. Hoodin, F., Kalbfleisch, K., Thorton, J., & Ratanatharathorn, V. (2004). Psychosocial influences on 305 adults’ survival after bone marrow transplantation: depression, smoking, and behavioral self-regulation. Journal of Psychosomatic Research, 57, 145-154. Horton-Deutsch, S., Day, P., Haight, R., & Babin-Nelson,M. (2007). Enhancing mental health services to bone marrow transplant recipients through a mindfulness-based therapeutic intervention. Complementary Therapies in Clinical Practice, 13, 110-115. Illescas-Rico, R., Amaya-Ayala, F., Jimènez-López, J., Caballero-Méndez, M., & González-Llaven, J. (2002). Increased incidence of anxiety and depression during bone marrow transplantation. Archives of Medical Research, 33, 144-147. Jacobsen, P. (2009). Promoting evidence-based psychosocial care for cancer patients. Psychooncology, 18, 6-13. Jacobsen, P. & Jim, H. (2008). Psychosocial interventions for anxiety and depression in adult cancer patients: achievements and challenges. A Cancer Journal for Clinicians, 58, 214-230. Lee, S., Loberiza, F., Antin, J., Kirkpatrick, T., Prokop, L., Alyea, E., Cutler, C., Ho, V., Richardson, R., Schlossman, R., Fisher, D., Logan, B., & Soiffer, R. (2005). Routine screening for psychosocial distress following hematopoietic stem cell transplantation. Bone Marrow Transplantation, 35, 77-83. Meyers, C., Weitzner, M., Byrne, K., Valentine, A., Champlin, R., & Przepiorka, D. (1994). Evaluation of the neurobehavioral functioning of patients before, during, and after bone marrow transplantation. Journal of Clinical Oncology, 12(4), 820-826. Molassiotis, A. (1999). Further evaluation of a scale to screen for risk of emotional difficulties in bone marrow transplant recipients. Journal of Advanced Nursing, 29(4), 922-927. Molassiotis, A., Boughton, B., Burgoyne, T., & VanDen Akker, O. (1995). Comparison of the overall quality of life in 50 long term survivors of autologous and allogeneic bone marrow transplantation. Journal of Advanced Nursing, 22, 509-516. Molassiotis, A., VanDen Akker, O., Milligan, D., Goldman, J., & Boughton, B. (1996). Psychological adaptation and symptom distress in bone marrow transplant recipients. Psycho-Oncology, 5, 9-22. NCCN Clinical Practice Guidelines in Oncology™ Distress Management (Version 1.2010). © 2009 National Comprehensive Cancer Network, Inc. Available at: NCCN.org. Accessed [Febuary 3, 2010]. Newell, S., Sanson-Fisher, R., & Savolainen, N. (2002). Systematic review of psychological therapies for cancer patients: overview and recommendations for future research. Journal of National Cancer Institute,94, 558- 584. Pirl, W. (2004). Evidence report on the occurrence, assessment, and treatment of depression in cancer patients. Journal of the National Cancer Institue Monographs, 32, 32-39. Prieto, J., Blanch, J., Atala, J., Carreras, E., Rovira, M., Cirera, E., & Castó, C. (2002). Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. Journal of Clinical Oncology, 20(7), 1907-1917. Ranson, S., Jacobsen, P., & Booth-Jones, M. (2006). Validation of the distress thermometer with bone marrow transplant patients. Psycho-Oncology, 15, 604-612. Rodrigue, J., Pearman, T., & Moreb. (2000). Morbidity and mortality following bone marrow transplantation: predictive utility of pre-BMT affective functioning, compliance, and social support stability. International Journal of Behavioral Medicine, 6(3), 241-254. Sherman, A., Simonton, S., Latif, U., Plante, T., Anaissie, E. (2009). Changes in quality of life and psychosocial adjustment among multiple myeloma patients treated with high-dose melphalan and autologous stem cell transplantation. Biology of Blood and Marrow Transplantation, 15, 12-20. Syrjala, K., Langer, S., Abrams, J., Storer, B., Sanders, J., Flowers, M., & Martin, P. (2004). Recovery and long- term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA, 291(19), 2335- 2343. Trask, P., Paterson, A., Riba, M., Brines, B., Griffith, K., Parker, P., Weick, J., Steele, P., Kyro, K., & Ferrara, J. (2002). Assessment of psychological distress in prospective bone marrow transplant patients. Bone Marrow Transplantation, 29, 917-925. Wells, K., Booth-Jones, M., & Jacobsen, P. (2009). Do coping and social support predict depression and anxiety in patients undergoing hematopoitic stem cell transplantation? Jouranl of Psychosocial Oncology, 27, 297- 315. Wenzel, L., Glanz, K., & Lerman, C. (2002). Stress, coping, and health behavior. In. K. Glanz, B.K. Rimer, & F.M. Lewis (Eds.), Health behavior and health education: Theory, research, and practice (pp. 210-239). San Fansico: Jossey-Bass. Williams, S. & Dale, J. (2006). The effectiveness of treatment for depression/depressive symptoms in adults with cancer: a systematic review. British Journal of Cancer, 94, 372-390.
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